Chromosomes are composed of a mixture of proteins and DNA called chromatin, the basic unit of which is the nucleosome. Nucleosomes consist of histone proteins, and help to organise DNA by acting as a spindle around which DNA winds. To understand how chromatin is assembled, Genevieve studies a protein complex called CAF1 that helps DNA to wind around nucleosomes. She has discovered that CAF1 helps to assemble new DNA into chromatin every time the genome is copied for a new cell and also that CAF1 helps to maintain chromatin structure while DNA damage is repaired by repair proteins.