Adrian studies DNA methylation, which is a chemical alteration of DNA that encodes an additional layer of information over and above the DNA sequence. DNA methylation plays a major role in gene silencing and Adrian has found proteins that bind to methylated DNA sequences and mediate this effect. Mice lacking one such protein, called MeCP2, develop a condition that mimicks the human neurological condition Rett Syndrome. By investigating which genes are inappropriately switched on in MeCP2-deficient mice, Adrian hopes to facilitate therapeutic strategies for this disorder.