Amanda and her partner, Matthias, are interested in cell fate. Their team use white blood cells to figure out how such genetically identical units progress to different end points. They’re well aware that in order to specialize, cells need to switch a lot of genes off. But how does the memory of a cell evolve? How does it know which genes to silence? Proteins like Ikaros, they discovered, can influence cell fate by shutting genes up permanently.  Where a gene is positioned, and when it gets copied are also key factors in gene lock-down.