Frank investigates how the beta-globin gene locus is regulated. Beta-globin is a constituent of haemoglobin, which is only made in red blood cells to transport oxygen around the body. How does it get switched on in red blood cells? The answer is a regulatory sequence of DNA called the Locus Control Region (LCR), which ensures the gene is only accessible to the proteins required to switch it on in red blood cells. Frank studies how the LCR interacts with the beta-globin gene even though it is not right next to it.