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Both genetic and epigenetic switches control whether genes are switched on or off. Proteins encoded in the DNA sequence called transcription factors act as genetic gene switches, while epigenetic switches include chemical modifications of DNA and associated histone proteins, as well as alterations in the structure of chromatin, the mixture of proteins and DNA that makes up chromosomes. Moshe studies how genetic and epigenetic gene switches are involved in a wide range of biological processes including Type II diabetes, polycystic kidney disease, the development of organs such as the heart and liver, and how cells become cancerous.

Moshe recently retired from his career as a research scientist and from the network