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Manel wants to discover what is the contribution of epigenetics in health and disease. Starting from identical genetic sequences, changes in histone modifications and DNA methylation can produce organisms with different features and distinct susceptibility to sickness. A good example are monozygotic twins. To have a complete picture of what is going on with the epigenetic tapestry of our cells, Manel is a firm advocate of the development of a comprehensive Human Epigenome project to map all the epigenetic marks in our genetic material. This ambitious goal will have a huge impact in cancer patients, because we already know that malignant cells have a profound disregulation of DNA methylation and histone modification patterns. The good news is that the first pharmacological compounds to "restore" the normal epigenetic landscapes are starting to emerge.