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Kristian is interested in identifying and characterizing novel genes and mechanisms involved in the development of human cancer. The laboratory has identified a number of proteins that regulate transcription by making the DNA more accessible, or by regulating the methylation status of the histones. These proteins, which include histone methyl transferases, histone demethylases and Polycomb Group proteins, control important cellular decisions such as proliferation, differentiation and stem cell maintenance. Importantly, their deregulation can cause cancer and they may therefore be excellent targets for developing novel anti-cancer drugs.