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Wouter wants to understand how 2 meters of DNA is packed into the tiny cell nucleus, and if and how processes like transcription influence the folding of DNA. His group recently developed a high-throughput method (called 4C technology) to systematically screen the entire genome for DNA stretches that interact with each other in the nuclear space. They showed that active genes contact each other on the same chromosome and on other chromosomes, while inactive genes preferentially make long-range contacts with inactive DNA regions. 4C technology is expected to guide science towards a comprehensive understanding of nuclear architecture.