Institute website

Maarten studies the Polycomb group of transcription factor proteins. Polycomb group proteins regulate Hox genes, which must be turned on or off at the right time and in the right place for humans and other organisms to develop correctly. Maarten’s research group has shown that Polycomb group proteins are essential in special cells called stem cells, which are needed to replenish cells in all of our organs. If Polycomb group proteins are not properly regulated, developmental abnormalities, aberrant stem cell proliferation can result. He is also trying to identify proteins called tumour suppressors.