Institute website

DNA encodes the genetic information of our cells, which is dictated by the order of four bases: adenine, cytosine, guanine and thymine. The presence of the modified base, 5-methylcytosine, in animal DNA is essential for correct gene regulation and for genome stability. Its importance is underlined by the observation of aberrant patterns of DNA methylation in the development of many cancers and in human disease. Richard’s lab produces cells lacking DNA methylation and observes what goes wrong in them. His work contributes to new insights on the nature of stem cells and the development of safe health care applications.