Lab website

At any one time, only a subset of our ~22 000 genes is switched on and the rest are silenced. For a gene to be silenced, its chromosomal or chromatin environment must be in a silent state. One way of generating silent chromatin states is by performing deacetylation of histone proteins, a chemical modification of proteins that bind to chromosomal DNA. Another way is to silence the genes using small RNA molecules in a process called RNA interference. Karl is trying to make a map of the whole genome showing where acetylation marks and small RNA molecules exist to see how they affect gene activity.