Institute website

When he’s not singing in a choir, Antoine studies how mammalian embryos have the potential to develop into many different cell types. Chemical modifications of DNA or of histones, proteins that bind to DNA, contribute to the specification of particular cell types. Such epigenetic modifications must be erased and reset during the production of sperm and egg cells, a process known as epigenetic reprogramming, to enable the embryo to develop into a baby with different cell types. Antoine focuses on how histone methylation, a chemical modification of histones, influences epigenetic reprogramming.