Lab

DNA of all nucleated cells is stored in a complex with histone proteins called chromatin. Changes in chromatin structure determine the way genes can be activated or repressed. The properties of chromatin are determined by chemical modifications of the histones (e.g. post-translational marks). Several different types of post-translational chromatin modifications exist and there are many different positions where histones can be marked. Wolfgang is studying the mechanisms by which single markers and combinations of markers change the properties of chromatin. He could show that different markers are recognized and bound by specialized proteins. These read the patterns of modifications and thereby coordinate the structure of chromatin.