Lab website

To fit the long string of DNA into the small cell nucleus a high compaction is required, but at the same time the DNA has to stay accessible e.g. to be read out. One main player for this organisation of DNA into highly compacted chromatin is the 'linker' histone H1. Our aim is to understand how chemical modifications of H1 can regulate DNA accessibility, how these modifications can determine whether certain genes are on or off and how these marks are passed on into the next cell generation.