Baker’s yeast cells are very similarly organised as our own cells and useful for asking fundamental questions about the organization of DNA in the cell nucleus and how this influences gene regulation. This organisation, the so-called chromatin structure, is the molecular basis of epigenetic information. Philipp studies chromatin changes upon switching genes on or off in yeast. In order to understand the underlying biochemical mechanisms he does not only observe what happens in living yeast, but also works on the reconstitution of chromatin structure and dynamics from isolated components.