Institute website

Most of us agree to the concept that order allows efficient retrieval of stored things and information. How does the cell organize the genome to activate the right gene when needed and to keep it silent at other times? Part of this organization relies on changing the packaging of DNA by modifying proteins within nucleosomes (histones). Since different tissues express different genes this packaging creates an additional and dynamic map that has been dubbed the epigenome. In our group we are trying to decipher such epigenetic roadmaps by studying thousands of genes in a single experiment. With this information we hope to understand the organization principles of the genome and how its misregulation can contribute to disease.